Unaweep/Tabeguache is in western Colorado and begins about ten miles south of Grand Junction. The byway follows CO 141 and CO 145 for 133 miles and ends in Placerville. Both state highways are two-lane paved roads suitable for all types of vehicles. The byway is usually open year-round but snow removal in winter may cause delays.
The byway circles the Uncompahgre National Forest, traveling through 1,200-foot granite walls rising above lush green fields. This area was once the home of Ute Indians and a hideout for Butch Cassidy. Structures built by Native American hunters and gatherers, petroglyphs, geological formations, and waterfalls are some of the highlights of the byway.
A variety of wildlife inhabits this region of Colorado including black bear, mountain lion, bobcat, coyotes, and various rodents and reptiles. The large meadows and south-facing canyon slopes provide winter habitat for mule deer and elk. Wild turkeys and pheasants may also be spotted in the meadows. During the winter months, the watchful eye may catch glimpses of bald eagles perched in the cottonwood trees along West Creek or the Dolores and San Miguel rivers.
Abandoned mines and mills quietly testify to the mining history of this area. Attached to the sheer canyon walls above the Dolores River are portions of the Hanging Flume, which was built in the late 1800s to carry water from the San Miguel River to placer mines in the canyon.
The many side roads found along the byway lead into the Uncompahgre National Forest and offer challenges to four-wheel drive and mountain bike enthusiasts. The national forest also has several developed camping areas available.